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NeuroBlu Data

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Alzheimer’s Disease Dataset

THE CHALLENGE

Across the pharmaceutical industry, teams struggle to access the depth and completeness of real-world data (RWD) needed to answer critical questions in Alzheimer’s Disease (AD).

The lack of integrated data in dementia care, spanning geriatrics, neurology, and psychiatry, limits the ability to assess disease burden, model progression, and understand treatment patterns, forcing pharma teams to make high-impact decisions on incomplete evidence.

This results in slow innovation, weakens payer and HTA submissions, and increases risk across both pipeline and in-market strategies. Existing datasets often lack the clinical detail required to capture the full patient journey, including cognitive scores, neuropsychiatric symptoms, and laboratory results, gaps that are especially problematic in complex cases of Alzheimer’s disease, early dementia, and Mild Cognitive Impairment (MCI). Neuropsychiatric symptoms, which may emerge at any stage of Alzheimer’s disease, create significant clinical, economic, and caregiver burdens, yet remain poorly documented in most real-world data (RWD) sources.

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THE SOLUTION

NeuroBlu Data delivers the most clinically rich EHR-based dataset for Alzheimer’s disease and Mild Cognitive Impairment (MCI). Spanning 10+ years, NeuroBlu integrates structured data with NLP-enriched clinical notes to capture the nuances of care in the real world, including cognitive assessments (Montreal Cognitive Assessment (MoCA), Mini-Mental State Examination (MMSE), Mini-COG), detailed neuropsychiatric symptoms (agitation, hallucinations, apathy, depression, anxiety), biomarkers (tau, amyloid), genetic markers (APOE ε3/ε4), and neuroimaging testing use (PET, MRI, CT).

439k+  Patients with Alzheimer’s Disease
322k+  Patients with Mild Cognitive Impairment

By linking these data with tokenized claims, labs, and other RWD sources, NeuroBlu enables true longitudinal patient journeys across outpatient and inpatient care settings, a level of integration and phenotyping unmatched by others.

NeuroBlu Data enables pharma teams to:

Leverage NLP-enriched clinical notes

To capture clinical context and nuances (symptom severity, caregiver observations, ADL changes, crisis events, and treatment rationale) that structured data alone misses.

Identify neuropsychiatric symptoms

Such as agitation, aggression, and psychosis, as a consequence of integrating data from geriatrics, neurology, and psychiatry, and assessing their impact on patient outcomes, and healthcare resource utilization (HCRU).

Deep phenotyping acrossed the disease continuum

From early cognitive decline through advanced Alzheimer’s across multiple care settings, phenotyping by stage (MCI, moderate, severe AD) and behavioral profile (e.g., apathy & agitation).

Evaluate real-world treatment patterns

Including prescribing practices at diagnosis, treatment sequencing, rationale for changes, discontinuations, side effects, and progression.

Data tokenization and linkability

Enables tokenization and linkability with claims, labs, imaging, genetics, and other real-world data sources, seamlessly integrating disparate streams into a unified longitudinal patient journey that reflects the full complexity of Alzheimer’s disease.

Delivered with rapid onboarding and frequent refreshes, NeuroBlu Data empowers HEOR, epidemiology, market access, medical affairs, and commercial teams.

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THE IMPACT

HEOR & RWD

  • Model disease burden and progression with unprecedented depth, integrating cognitive scores (MoCA, MMSE, Mini-COG), neuropsychiatric symptoms (agitation, apathy, depression, psychosis, anxiety), caregiver observations, ADL changes, crisis events, biomarkers (tau, amyloid), genetics (APOE ε3/ε4), and neuroimaging (PET, MRI, CT).
  • Quantify healthcare resource utilization (HCRU) and cost drivers across the full Alzheimer’s spectrum (MCI → severe AD), powered by tokenization and linkage with claims, labs, and imaging for a complete economic and clinical picture.
  • Conduct advanced phenotyping and subpopulation analyses by stage (MCI, moderate, severe AD) and behavioral profile (e.g., agitation, psychosis), enabling deeper subgroup characterizations such as biomarker-confirmed or APOE4-positive patients.
  • Support causal inference, time-to-event modeling, and predictive analytics for progression, symptom onset, and treatment outcomes, accelerating HEOR, epidemiology, and value demonstration for payer and HTA submissions.

Market Access & Medical Affairs

  • Identify unmet needs and opportunities for earlier intervention, detecting cognitive decline and neuropsychiatric symptoms that precede or go undocumented as MCI/AD diagnoses.
  • Profile treatment-responsive subgroups by linking clinical, biomarker, genetic, and symptom data, enabling precision medicine strategies and real-world identification of patients most likely to benefit.
  • Assess drug safety in diverse, real-world populations, including subgroup-level risk stratification (e.g., ARIA-E/ARIA-H monitoring among APOE4 carriers).
  • Characterize real-world diagnostic and treatment practices across neurology, psychiatry, and geriatrics, capturing biomarker adoption, disease-modifying treatment uptake, and rationale for care decisions as recorded in NLP-enriched notes.

Commercial & Marketing

  • Map real-world treatment patterns and sequencing, including prescribing at diagnosis, rationale for changes, discontinuations, side effects, and progression across specialties and settings.
  • Segment patient populations for brand strategy by combining cognitive stage, behavioral phenotype, and biomarker status to surface high-priority subgroups (e.g., biomarker-positive, mildly impaired patients with agitation or apathy).
  • Support market shaping and value messaging with granular, data-driven insights into diagnostic pathways, treatment initiation, and site-level variation, quantifying, for example, how often patients receive biomarker confirmation prior to treatment start.
  • Differentiate brand positioning through evidence of real-world burden and patient journeys, drawing on longitudinal, tokenized data that uniquely reflects the full complexity of Alzheimer’s disease.

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